Crystalline Methylcobalamin from a Microorganism.

Methyl transfer from methylcobalamin to diaquocobinamide.

The transfer of the methyl group from methylcobalamin to diaquocobinamide in aqueous solution has been demonstrated by proton, carbon-13, and phosphorus-31 nuclear magnetic resonance spectroscopy. The products of this reaction are aquocobalamin and the methylaquocobinamides. Dicyanocobinamide and the cyanoaquocobinamides do not serve as methyl acceptors, while ligands such as pyridine and histi...

Staurosporine, a potentially important gift from a microorganism.

Discovery of Staurosporine Chemical Properties of Staurosporine A. Structure B. Hydrophobicity C. Binding Domain of Staurosporine Inhibitory Activity of Staurosporine against Protein Kinases in Vitro A. Protein Kinase C and Myosin Light Chain Kinase B. Protein Kinases A and G, and Other Serine/Threonine Kinases C. Tyrosine Kinases Biological Activities of Staurosporine A. Relaxation of Smooth M...

Methylcobalamin: A Potential Vitamin of Pain Killer

Methylcobalamin (MeCbl), the activated form of vitamin B12, has been used to treat some nutritional diseases and other diseases in clinic, such as Alzheimer's disease and rheumatoid arthritis. As an auxiliary agent, it exerts neuronal protection by promoting regeneration of injured nerves and antagonizing glutamate-induced neurotoxicity. Recently several lines of evidence demonstrated that MeCb...

A New Thermophilic Nitrilase from an Antarctic Hyperthermophilic Microorganism

Several environmental samples from Antarctica were collected and enriched to search for microorganisms with nitrilase activity. A new thermostable nitrilase from a novel hyperthermophilic archaea Pyrococcus sp. M24D13 was purified and characterized. The activity of this enzyme increased as the temperatures rise from 70 up to 85°C. Its optimal activity occurred at 85°C and pH 7.5. This new enzym...

A Filterable Yeast-like Microorganism